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Description:This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution CC-BY license http: This article has been cited by other articles in PMC. Abstract The normal developmental program that prolactin generates in the mammary gland is usurped in the cancerous process and can be used out of its normal cellular context at a site of secondary metastasis. Prolactin is a pleiotropic peptide hormone and cytokine that is secreted from the pituitary gland, as well as from normal and cancerous breast cells. Experimental and epidemiologic data suggest that prolactin is associated with mammary gland development, and also the increased risk of breast tumors and metastatic disease in postmenopausal women. The breakdown of the bone matrix, in turn, enhances the proliferation of the cancer cells, creating a vicious cycle.
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